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Euglycemic Diabetic Ketoacidosis: A Review

机译:正常血糖糖尿病酮症酸中毒的综述

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Introduction: Diabetic ketoacidosis (DKA) is one of the most serious complications of diabetes. It is characterised by the triad of hyperglycemia (blood sugar >250 mg/dl), metabolic acidosis (arterial pH <7.3 and serum bicarbonate <18 mEq/L) and ketosis. Rarely these patients can present with blood glucose (BG) levels of less than 200 mg/dl, which is defined as euglycemic DKA.. The possible etiology of euglycemic DKA includes the recent use of insulin, decreased caloric intake, heavy alcohol consumption, chronic liver disease and glycogen storage disorders. DKA in pregnancy has also been reported to present with euglycemia. The recent use of sodium glucose cotransporter 2 (SGLT2) inhibitors has shed light on another possible mechanism of euglycemic DKA. Clinicians may also be misled by the presence of pseudonormoglycemia.
机译:简介:糖尿病酮症酸中毒(DKA)是糖尿病最严重的并发症之一。其特征是高血糖(血糖 >250 mg/dl)、代谢性酸中毒(动脉 pH <7.3 和血清碳酸氢盐<18 mmol/L)和酮症三联征。极少数情况下,这些患者的血糖 (BG) 水平低于 200 mg/dl,这被定义为正常血糖 DKA。正常血糖 DKA 的可能病因包括近期使用胰岛素、热量摄入减少、大量饮酒、慢性肝病和糖原贮积障碍。据报道,妊娠期糖尿病酮症酸中毒也表现为正常血糖。最近使用钠葡萄糖协同转运蛋白 2 (SGLT2) 抑制剂揭示了正常血糖 DKA 的另一种可能机制。临床医生也可能被假性正常血糖的存在所误导。

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