首页> 外文期刊>The Anatomical record >Role of mesenchymal cells in the neovascularization of the rabbit phallus
【24h】

Role of mesenchymal cells in the neovascularization of the rabbit phallus

机译:间充质细胞在兔新生血管形成中的作用

获取原文
获取外文期刊封面目录资料

摘要

AbstractThe neovascularization of the rabbit phallus at ages between prenatal days 15 and 21 was investigated by light‐ and electron microscopy, computer‐aided light microscopic reconstruction, and immunocytochemistry. The phalli are embedded by an abundance of mesenchymal cells, which are in contact with the neighboring ones or with the endothelial lining of growing capillaires. They often form solid cell cords that eventually make contact with the growing capillaries. The computer‐aided reconstruction of the serial light micrographs reveals that these cell cords are involved in connecting the adjacent capillaries. The incorporation of such mesenchymal cell projections into the endothelial lining, occasionally conjugated with simple attachement devices, is frequently observed by transmission and scanning electron microscopy. The contact areas between the mesenchymal and endothelial cells show immunoreactions of fibronectin.These results indicate the successive transformation of mesenchymal cells to endothelial cells of the growing capillaries. As endothelial cells of the growing capillaries show mitotic proliferation, such vasoformative mesenchymal cells seem to be involved in the acceleration of the neocapillarization of the rabbit phallus. Fibronectin actively produced in the mesenchymal cells may participate in their migration and the mechanical linkage with the endothelial cells. © 1994 Wiley‐L
机译:摘要 采用光电显微镜、计算机辅助光显微镜重建和免疫细胞化学等手段研究产前15-21岁兔的新生血管形成情况。被大量的间充质细胞嵌入,这些间充质细胞与相邻的间充质细胞或与生长中的毛细血管的内皮内膜接触。它们通常形成固体细胞索,最终与生长中的毛细血管接触。连续光学显微照片的计算机辅助重建显示,这些细胞线参与连接相邻的毛细血管。这种间充质细胞投射到内皮衬里,偶尔与简单的附着装置偶联,经常通过透射和扫描电子显微镜观察到。间充质细胞和内皮细胞之间的接触区域显示纤连蛋白的免疫反应。这些结果表明间充质细胞连续转化为生长中的毛细血管的内皮细胞。由于生长中的毛细血管的内皮细胞显示出有丝分裂增殖,这种血管形成性间充质细胞似乎参与了兔新毛细血管化的加速。在间充质细胞中活跃产生的纤连蛋白可能参与其迁移以及与内皮细胞的机械连接。© 1994 威利-L

著录项

获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号