Inhibitory effect of inhaled procaterol on anaphylactic bronchoconstriction and thromboxaneA2production in guinea‐pigs

摘要

SummaryThis study was designed to examine whether an inhaled β2‐agonist, procaterol, inhibits thromboxane A2(TXA2) production induced by antigen challenge in passively sensitized guinea‐pigsin vivo. Antigen‐induced bronchoconstriction was markedly inhibited by pre‐treatment with procaterol. Inhaled procaterol significantly reduced in a dose‐dependent manner the increment in TXB2concentration in bronchoalveolar lavage fluid obtained 5 min after antigen challenge. Aerosol administration of procaterol significantly inhibited bronchoconstriction induced by inhaled hislainine. These results suggest that inhalation of procalerol has an inhibitory effect on antigen‐induced TXA2production as well as a protective effect against bronchoconstriction induced by bronchoa