Neuronal nicotinic receptors: from protein structure to function

摘要

Neuronal nicotinic acetylcholine receptors are a prototype of ligand-gated channels that mediate transmission in the central and peripheral nervous system. Structurendash;function studies performed at the amino acid level are now unraveling the determinant residues either for the properties of the ligand-binding domain or the ionic pore. In this work we review, in the light of the latest finding, the structurendash;function relationship of these receptors and their implication in neurological diseases.