Identification of the nuclear transcription factor NFkappa;B in rat brain after in vivo ethanol administration

摘要

NFkappa;B a nuclear transcription factor, was induced in the brain nuclear fraction of naive rats after an acute injection of ethanol, 2 g/kg. In contrast, rats which had been chronically alcoholised showed the constitutively active NFkappa;B-like complex only after a further acute dose of ethanol. Hepatic nuclear fractions did not exhibit the specific NFkappa;B-like complex during the first 45 min after acute ethanol injection, beyond that which was normally constitutively present. Such activation of NFkappa;B-like complex in the brains of the naive rats may play an important role in the cellular protective response.