The human endogenous retrovirus K (HERV-K)-encoded protein cORF has recently been shown to be a functional homolog of the HIV Rev protein. Rev-mediated RNA export requires interaction between a leucine-rich nuclear export signal (NES) in Rev and the nuclear export receptor Crm1/exportin1. Like Rev, cORF binds to Crm1 and cORF-mediated RNA export depends on Crm1 activity. Here we document that mutation of the putative NES in cORF results in trapping of the protein in the nucleus, suggesting that the cORF NES functions in analogy to the Rev NES.
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机译：人类内源性逆转录病毒 K （HERV-K） 编码的蛋白 cORF 最近被证明是 HIV Rev 蛋白的功能同源物。Rev 介导的 RNA 输出需要 Rev 中富含亮氨酸的核输出信号 （NES） 与核输出受体 Crm1/exportin1 之间的相互作用。与 Rev 一样，cORF 与 Crm1 结合，cORF 介导的 RNA 输出取决于 Crm1 活性。在这里，我们记录了 cORF 中假定的 NES 突变导致蛋白质被困在细胞核中，这表明 cORF NES 的功能类似于 Rev NES。
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