Acceleration of Coagulation by Spectrin‐Free Erythrocytic Vesicles: Evidence for Lipid Flip‐Flop during Vesicle Formation

摘要

Abstract.Spectrin‐free erythrocytic vesicles isolated from outdated liquid‐preserved blood samples show a distinct increase of the clot‐promoting activity compared with membrane phospholipid equivalents of intact erythrocytes. We suppose that, among other remodelling processes, local spectrin detachment from the inner membrane surface may trigger a flip‐flop‐mediated disturbance of the membrane lipid asymmetry. The interactions of spectrin with the cytoplasmic membrane surface seem to be essential for the structural membrane integrity including the lipid