AbstractEstrogen secretion by the ovary, as estimated by changes in genital tract tissues, can be directly correlated with the appearance of eosinophilic granulated cells within the ovarian tissues. Ovarian eosinophilia and development of the genital tract of the gilt are prominent from the eleventh to fifteenth days of the estrous cycle, between the twenty‐fourth and forty‐fourth, and after the eighty‐sixth days of pregnancy. It is suggested that the appearance of eosinophilic granulated cells in ovarian tissues is a direct effect of ovarian estrogens, as is the appearance of genital tract eosinophilic granulated cells subsequent to estrogen release from the ovaries. The appearance of eosinophilic granulated cells in ovarian tissues provides a means whereby the portion of the ovary involved in estrogen secretion can be identified. Eosinophilic granulated cells were observed in thecal layers of secondary, tertiary and atretic follicles and in the connective tissues surrounding and penetrating recently formed corpora lutea. Ovarian eosinophilic granulated cells are not of immediate blood origin, but arise from undifferentiated mesenchymal cells. In the process of accumulation of eosinophilic granules and modification of nuclear chromatin to bi‐ or multinucleated forms, cellular death occurs and the granules and chromatin particles are released in the
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