Correction of Renal Bicarbonate Wastage by Parathyroidectomy

摘要

Systemic acidosis due to renal bicarbonate wastage is shown in four of six cases of primary hyperparathyroidism. Reduction of maximum tubular reabsorptive capacity (TmHCO3) appears to determine the newly stabilized plasma bicarbonate setting, and is itself proportional to reduction in tubular phosphate reabsorption. Parathyroidectomy was followed by elevation of TmHCO3. The results lead to a hypothesis that TmHCO3and, therefore, systemic acid-base balance may be at least partly controlled by a feed-back system based on parathormone secretion.