Production of immune interferon is regulated by more than one T cell subset: Lyt‐1,2,3 and Qat‐5 phenotypes of murine T lymphocytes involved in IFN‐γ production in primary and secondary mixed lymphocyte reaction

摘要

AbstractLymphocytes responsible for the production of IFN‐γ (immune interferon) in primary and secondary mixed lymphocyte reactions have been characterized with antisera specific for the Lyt‐1,2,3 and Qat‐5 alloantigens. A comparison was made between selected T cell subsets with respect to their ability to proliferate, generate cytolytic activity and produce IFN‐γ in response to H‐2 alloantigens.The data indicate that (a) in primary mixed lymphocyte reactions, IFN‐γ is produced by Lyt‐1+, Qat‐5+and by Lyt‐123+, Qat‐5+T cells, (b) in secondary mixed lymphocyte reactions, an additional T cell subset, which is Lyt‐23+, Qat‐5−, participates in the generation of IFN‐γ and (c) the production of IFN‐γ does not correlate with either proliferation or the g