An emulsion of pioglitazone hydrochloride (drug) was prepared by mixing drug:polymer (gelatin) in different ratios of 1:0.5,1:1, and 1:1.5 (wt/wt), respectively. These emulsions were used for the preparation of tablets of different composition. Tablet hardness increased with a decrease in concentration of polymer, while the percentage friability increased with an increase in polymer concentration in the tablet. The encapsulated tablet showed better sustained release than conventional tablets. The effect of concentration of polymer on dissolution rates of these tablets was studied using the Hixson-Crowell cube root law equation. The data obtained prove that the formulations are useful for a sustained release of pioglitazone hydrochloride, since the percentage released after 24 h was nearly 76. The release of pioglitazone hydrochloride was influenced by the presence of polymer and different compositions of lactose. The tablet containing an emulsion of ratio 1:0.5 showed an excellent result of rate constant, better than conventional and other compositions.
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