Corticosteroidshyphen;Salicylate Interaction in a Case of Juvenile Rheumatoid Arthritis

摘要

In an 11-year-old child with juvenile rheumatoid arthritis (JRA), the addition of prednisone caused a significant decrease in salicylate serum con-centrations. A pharmacokinetic assessment suggested that these changes were not the result of altered compliance or impaired absorption of salicylate but rather an increase in salicylate clearance induced by the corticosieroid.