Quantitative Structure Retention Relationship Studies of Some Basic Antimalarial Compounds

摘要

Studies have been made of the correlation between chromatographic retention parameter, k' and solute hydrophobicity as determined by the oil-in-water partition coefficient. Using a set of 29 basic antimalarial drugs and analogues such correlations have been made under ion pairing and non ion pairing conditions. The capacity factors have been obtained extrapolated to pure water and in the case of ion pairing conditions, the k'max values have been used.