The effect of Q-7, its metabolites and related compounds on antibody formation, was investigated. From the determination of passive hemagglutination titer, the stimulation of the antibody formation was observed in the sera of mice dosed with Q-7 and Q acid-II at 3 and 5 weeks after immunization. As the possible mechanism of the stimulation, the enhancement of a phagocytic activity by the reticuloendothelial system was considered. Release of splenic lysosomal enzyme activities in the dosed group was more at 1 week after immunization than that in the control group, whereas it was less at 3 weeks in the dosed group showing the stabilization of the lysosomal membrane.
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