Eight cases of central nervous system infection due to La Crosse (California serogroup) virus were detected in Georgia children in 1982. The patients were residents of the state, without histories of travel away from the vicinities of their homes during the 30 days before the onset of their illnesses. All were hospitalized with a diagnosis of aseptic meningitis or encephalitis; none had sequelae. Onset dates were from May 1 to Aug 30. Distribuion of cases within the state suggested that active transmission of La Crosse virus occurred at least in the southeast quadrant of the state. The epidemiology and natural cycle of La Crosse in the southeastern United States are briefly discussed.
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