Utility of a proliferation marker in distinguishing between benign naevocellular naevi and naevocellular naevus-like lesions with malignant properties

摘要

In the present study we have investigated the utility of the proliferation marker MIB1 in distinguishing between benign naevocellular naevi and naevocellular naevus-like lesions with malignant potential. Percentages of MIB1 immunoreactivity in the intradermal portion of the lesions were determined. In benign congenital and acquired naevi, as well as in dysplastic naevi, there was no or only a slight intradermal melanocytic proliferation (0-2percnt;), whereas vertical growth phase melanomas exhibited a substantial proliferative activity (11-48percnt;). In five cases of naevus-like lesions, which had all relapsed as unmistakable malignant melanomas (locally or metastatically) after primary surgery, there was also clear proliferative activity (9-67percnt;). Our findings suggest that MIB1 may be a useful tool in the routine histopathological examination of problematic naevocellular lesions.