Diversity in the biological properties of anti‐influenza cytotoxic T cell clones

摘要

AbstractThis study reports the examination ofin vivoandin vitroproperties of an antigendependent murine cytotoxic T cell (Tc) clone T5/5 specific for type A influenza virus. This clone differs morphologically and in its migratory pattern and biological properties from a previously examined anti‐influenza Tcclone L4 which grew in T cell growth factor independently of antigen. Unlike Tcclone L4, T5/5 cells do not release significant amounts of immune interferon on contact with influenza‐infected target cells nor do they limit virus replicationin vivo, although they efficiently lyse influenza‐infected target cells and can release interferon in the presence of concanavalin A. Thus individual Tcclones vary in function and further work is required to establish the properties of Tcthat are associated with host protection against virus infe