Protein kinase C isozyme expression in human leukemia–lymphoma cell lines—an immunocytochemical study

摘要

AbstractThere have been an increasing number of reports describing a pivotal role for phosphorylation in cellular responses for cell differentiation and proliferation. We examined an immunocytochemical expression of protein kinase C(PKC) isozymes (type I, II, and III) in 22 leukemia–lymphoma cell lines. Of these cell lines, 21 expressed type II PKC and 17 showed the co‐expression of both types II and III PKC in varying degree. The cell line without PKC activity showed far less 3H‐TdR uptake and no heterotransplantation in nude mice.Types II and III PKC appear to relate to cell proliferation in certain leukemia–lymphoma cel