There are few people in the world who have started out as researchers in the field of biosensors and have later shaped science policy and public opinion on science in their country as profoundly as Professor Isao Karube. As a young assistant professor and later as professor at the Tokyo Institute of Technology, he had already won fame for work on microorganism-based sensors which could be operated in a real industrial environment (assimilable sugars in a glutamic acid fermentation) or could be used to cut the time for BOD measurements from days to minutes. In these early days, he already commanded a net-work of industrial researchers who supplied him with the rich microelectronic heritage of Japan, in order to use these unique devices for the construction of novel types of disposable microbiosensors with a hitherto unheard of speed of signal detection (1 min or less).
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