Leukocyte chromosomes from parents of cytogenetically abnormal offspring: preliminary observations

摘要

The frequency of sporadic, hypermodal chromosomal spreads in cultures of leukocytes taken from the parents of aneuploids significantly exceeds that in comparison populations. Elimination of other possibilities suggests mitotic nondisjunction as the ultimate determinant for such spreads. This possibility requires that more attention be paid to the occurrence of hypermodal spreads, especially relative to the etiology of aneuploid concepti.