Vitamin E Supplementation Decreases Autoantibodies to Oxidized Lipid-Protein Complexes

摘要

Oxidation of low-density lipoprotein (LDL) has been suggested to be involved in the pathogenesis of atherosclerosis. Oxidized lipid-protein complexes are atherogenic, and autoantibodies to such complexes have been reported even in healthy humans and animals. We measured the titer of two such antibodies, antibodies to lipid peroxide-modified rabbit serum albumin (LOOH-RSA) and antibodies to copper-oxidized LDL (Cu-LDL), in normal subjects (n = 20) before and after 8 weeks of vitamin E supplementation (800 IU/day). Vitamin E levels in plasma doubled after 8 weeks of supplementation (from 3.76 ±0.6 to 6.44 ± 3.3 nmol/mg protein). After vitamin E supplementation the titer of antibodies to both LOOH-RSA (0.13 ± 0.01 OD versus 0.083 ± 0.001 OD) and Cu-LDL (0.137 ± 0.002 OD versus 0.103 ± 0.002 OD) decreased significantly. Our results suggest that levels of these antibodies can be controlled by antioxidant supplementation and that these levels might serve as indicators of the efficacy of antioxidants to attenuate the oxidative processesin