Technetium-99m complexes, specifically Tc-99m sestamibi, initially showed great promise as cardiac and parathyroid imaging agents at the time of their introduction in the 1980s. Since then, noncardiac and parathyroid applications have been expanding rapidly. The utility of Tc-99m sestamibi as a tumor imaging agent has been well demonstrated. Uptake by thyroid and bronchial carcinomas and by non-Hodgkinrsquo;s lymphoma has been documented. A 76-year-old woman was examined for evaluation of a presumed thyroid nodule. Ultrasound examination revealed a 1.1-cm nodule in the anterior left neck, which was thought to be a parathyroid adenoma. A Tc-99m sestamibi parathyroid scan showed abnormal uptake in the lateral left neck and left suprahilar region. Subsequent computed tomographic imaging and biopsy of a mesenteric soft tissue mass led to a diagnosis of malignant B-cell lymphoma.
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