SummarySynthesis of polymeric alloplasts capable of assimilation or integration with living tissues has become the newest concept in biomaterials research. A prosthesis coating material composed of polytetrafluroethylene and pyrolytic graphite has been synthesized according to biochemical and biomechanical tissue/prosthesis interface requirements. Molecular composition, surface chemistry, static geometry, and modulus of elasticity were the most important considerations in the design of this material.The coating material has high surface energy, 70 to 90 porosity with pore size ranging from 100 to 500 microns, and a modulus of elasticity comparable to that of fibrous connective tissue which actively invades and absorbs to the material. It has been used as a surface coating for prostheses in clinical and experimental surgery including femoral head prostheses, cruciate ligament appliances, augmenting devices of the alveolar ridge, zygomatic process and mental bone, heart valve stabilization, and tracheal ring prostheses. It has been used both in dogs and human beings. The success of the material has been dependent upon antisepsis, patient status, and consideration of biomechanical stressstrain restrictions.
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