*Note. Dr Price died unexpectedly in January 1976 while he was working on the Kimura neutral gene hypothesis. He had been investigating methods of programming and using a significance teat, due to W. J. Ewens (1972), and had been applying them to the date on enzyme polymorphisms collected in the Galton Laboratory. Although many of his papers have gone astray, some computer print‐outs have been saved. In view of the work he had put into these, the natural importance of the subject, the generous support given to him by the Medical Research Council, and the affection of his many friends, it would seem worth while publishing these results. No doubt he himself would have presented them differently; but the following paper attempts to set them out fairly. I am grateful for help, suggestions, and criticism from Professor H. Harris, Dr C. J. Hilditch, and especially from Professor W. J. Ewens, and also to Dr W. J. Hamilton who has succeeded in saving some of Dr Price's incomplete manuscripts. CEDRIC A. B. SMI
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