We identified aDrosophilagene encoding a homolog of the regulator of G-protein signaling (RGS) protein family. This gene (dRGS7) is expressed in neurons of the embryo and adult fly and is predicted to encode a 428-amino acid protein with>55 overall amino acid sequence identity with the vertebrate protein RGS7 and theC. elegansEGL-10. The dRGS7 protein is 50 conserved in the C-terminal RGS domain with RGS7 and EGL-10 but, remarkably, displays much greater conservation with the N-terminal regions of these proteins. This finding implies a conserved function for these homologs from divergent species involving domains outside the RGS domain. The dRGS7 protein also has a domain of similarity with Dishevelled and pleckstrin, raising the possibility that these proteins interact with common signaling components.
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