RATIONALE AND OBJECTIVES.Little information is available about the direct action of angiographic contrast media on vasoactive peptides and allergy-mediated substances in humans. This study defined the acute effects of iopromide, a nonionic contrast medium (370 mg/mL iodine), on vasoactive peptides, allergy-mediated substances, and hemodynnmic parameters in healthy volunteers.METHODS.Pulmonary digital subtraction angiography was performed in seven healthy volunteers with no cardiovascular or pulmonary disease. Iopromide was administered as a total volume of 100 mL through a 7-Fr catheter inserted in the right femoral vein. The injected volumes and duration of injection (15–20 mL/second) were kept constant. The following hemodynamic parameters were monitored continuously: results of electrocardiogram, heart rate, and phasic and mean pulmonary arterial and peripheral arterial pressures. Blood samples were obtained before and 3 to 5 minutes after injection of contrast media to determine the concentrations of the following vasoactive peptides: renin, angiotensin I-converting enzyme, angiotensin II, aldosterone, atrial natriuretic peptide, antidiuretic hormone, cyclic guanosine monophosphate, and myoglobin; and to allergy-mediated substances such as tryptase, cosinophil protein X, and eosinophil cationic protein, using radioimmunoassay techniques.RESULTS.Iopromide substantially increased atrial natriuretic peptide (48.8 ± 8.9 to 85.8 ± 13.0) and antidiuretic hormone (3.4 ± 0.3 to 4.6 ± 0.5) levels, whereas renin decreased (0.9 ± 0.1 to 0.8 ± 0.2) slightly but not significantly. Iopromide did not induce substantial changes in the other vasoactive peptides or in allergy-mediated substances after the contrast medium was injected. Similarly, cardiovascular parameters (heart rate, pulmonary and systemic blood pressures, and results of electrocardiogram) also remained unchanged after contrast injection.CONCLUSION.Iopromide caused no appreciable hemodynamic alterations associated with the changes in atrial natriuretic peptide and antidiuretic hormone and no evidence of allergy- mediated reactions in all volunteers.
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机译：基本原理和目标。关于血管造影剂对人体血管活性肽和过敏介导物质的直接作用的信息很少。本研究定义了碘普胺（一种非离子造影剂（370 mg/mL 碘）对健康志愿者的血管活性肽、过敏介导物质和血阴参数的急性影响。方法。对 7 名没有心血管或肺部疾病的健康志愿者进行肺数字减影血管造影。碘普胺通过插入右股静脉的 7-Fr 导管以 100 mL 的总体积给药。注射体积和注射持续时间（15-20 mL/秒）保持恒定。连续监测以下血流动力学参数&结肠;心电图、心率以及相位和平均肺动脉和外周动脉压的结果。在注射造影剂之前和之后 3 至 5 分钟采集血样，以确定以下血管活性肽和结肠的浓度; 肾素、血管紧张素I-转换酶、血管紧张素II、醛固酮、心房利钠肽、抗利尿激素、环磷酸鸟苷和肌红蛋白;以及过敏介导的物质，如类胰蛋白酶、余酸性粒细胞蛋白 X 和嗜酸性粒细胞阳离子蛋白，使用放射免疫测定技术。结果。碘普胺显著增加心房利钠肽（48.8±8.9至85.8±13。0）和抗利尿激素（3.4±0.3至4.6±0.5）水平，而肾素略有下降（0.9±0.1至0.8±0.2）略有下降，但不显著。注射造影剂后，碘普胺不会引起其他血管活性肽或过敏介导物质的实质性变化。同样，注射造影剂后心血管参数（心率、肺和全身血压以及心电图结果）也保持不变。结论。碘普胺没有引起与心房利钠肽和抗利尿激素变化相关的明显血流动力学改变，也没有证据表明所有志愿者都有过敏介导的反应。
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