Zur Synthese des 6,7-Dihydro-15-hydroxy-7,7-dimethylbenzo2,3 (1,6)-naphthyridino5,6-bchinazolin-9-ons

摘要

The reaction of1,1-dimethyl-3-oxobutylisothiocyanate1with methyl anthranilate takes place via the 2-(2-thioxopyrimidine-1)-benzoic methylester2 a, which is rearranged to the methyl thioxopyridineanthranilate3 a. 3 ais alkylated by methyl anthranilate to the corresponding methylthio-product4 a, which reacts with anthranilic acid via5ato the benzo 1,6naphthyridino5,6-b-chinazoline6. 6can also be synthesized by condensation of 2-methylthiopyridines9 a, bwith anthranilic acid and 4-dimethylaminpyridine-2-thione8awith methyl anthranilate resp.