Simple Chiral Liquid Chromatographic Enantioseparation of Some Racemic Antiepileptic Drugs

摘要

Cellulose tris (4-methylbenzoate) known as Chiralcel OJ chiral stationary phase (CSP) has been successfully used for the enantioseparation of three clinically used antiepileptic drugs namely, mephobarbital, mephenytoin and benzonal. The chemical structure-chiral recognition mechanisms related to the enantiomeric elution order of these dns are discussed.