AbstractA goat was dosed orally with 14Ctefluthrin, twice daily for 4 days, at a rate equivalent to 10.9 mg kg−1in its diet. Within 16 h of the final dose, 70.1 of the dose had been excreted (urine 41.4, faeces 28.7). Extensive metabolism occurred in the goat by ester cleavage and oxidation at a variety of positions on the molecule. Low radioactive residues were detected in the milk (0.076 mg kg−1), fat (0.076 mg kg−1) and muscle (0.016 mg kg−1), with tefluthrin as the largest individual component of the residue (milk 66.5, fat 76.7, muscle 34.2). Higher residues were present in the kidney (0.3 mg kg−1) and liver (1.0 mg kg−1) and only a small percentage of this residue was due to tefluthrin (kidney 3.4, liver 6.1). The remainder of the residue in the kidney and liver was a complex mixture of metabolites. Most of the kidney metabolites were identified, but a high proportion of the liver residue was due to six unidentified pola
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