DAPI-inducible common fragile sites

摘要

DAPI, a compound specific for the AT bases of DNA, causes gaps and breaks in three human chromosome sites, at the 1q41 1q42 interface, 2q31, and 7p22. It also induces undercondensation of a chromosome site at the 13q21–13q22 interface. The first three sites have the characteristics of “common fragile sites” and are present as gaps and breaks on the chromosomes of seven indivi