Pregnancy and pregnancy outcome in hepatitis C type 1B

摘要

A large cohort of rhesus-negative women in Ireland wereinadvertently infected with hepatitis C Virus following exposure tocontaminated anti-D Immunoglobulin in 1977-8. This major iatrogenicEpisode was discovered in 1994. We studied 36 Women who had beeninfected after their first Pregnancy, and compared them to an age-andParity-matched control group of rhesus-positive Women. The presenceof hepatitis C antibody was Confirmed in all 36 by enzyme-linkedimmuno- Sorbent assay and by recombinant immunoblot Assay, while 26(72/100) of the cohort were HCV- RNA-positive (type 1b) on PCRtesting.