In vitroinvestigations in asthmatic children undergoing hyposensitization with tyrosine‐adsorbedDermatophagoides pteronyssinusantigen

摘要

SummarySuccessful hyposensitization toDermatophagoides pteronyssinusin perennial childhood asthma was associated with a slight mean rise of serum IgG antibody to the mite antigen in contrast to a placebo group in whom this antibody fell slightly. No relationship was detected between the effect on asthma and the magnitude of this change, Nor was there any consistent effect on IgE or IgA antibody.There was a wide range of total serum IgE and IgE, IgG and IgA antibody toD. pteronyssinusbefore treatment; this level did not predict the effect of treatment. Some patients lacked IgA antibody.IgE antibody to timothy grass pollen was raised in some but not others. These levels did not change systematically during the study and improvement occurred in those who had this antibody as well as IgE antibody toD. pteronyssinus.IgG and IgE antibodies toD. pteronyssinuswere significantly correlated in the pre‐treatment samples.Lymphocyte thymidine uptake was lower after 8 weeks of treatment than in the control group, not only after stimulus withD. pteronyssinusantigen,in vitro, but also with antigen fromCandida albicans.This was not a serum effect.The late bronchial provocation response was lost only in those with serum IgA less than the log mean for ag