Reverse phase high-performance liquid chromatography methods for the quantitation of glipizide and glyburide in tablets have been developed. The methods are accurate and precise with a percent relative standard deviations based on 6 injections of 0.8 and 0.3 for glipizide and glyburide, respectively. The developed methods can be used to test the content uniformity of the tablets. The extraction procedure for the active ingredients from the tablets is very simple. There is no interference from the excipients and the acid hydrolyzed samples showed new peak in the chromatograms.
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