Acetylenic chemistry, part 20: Ring opening of 3-azaisatoic anhydride with acetylenic amines: Synthesis of pyrido2,3-dpyrimidinones

摘要

Ring opening of 3-azaisatoic anhydride with acetylenic amine gave the nicotinamides3 a–c. The reaction of triphosgene with the nicotinamides3 a–cyielded the pyrido2,3-dpyrimidinones4a,5b,5c, an