Disoriented Behavior in Familiar Surroundings Is Strongly Associated with Perceptual Impairment in Mild Alzheimer's Disease

摘要

42 outpatients with mild Alzheimer''s disease were studied to investigate the hypothesis that neuropsychological measures which indicate right hemisphere dysfunction, like deficits in visuoconstructive and perceptual tasks, are associated with disoriented behavior in familiar surroundings. The only measure associated with disoriented behavior was the measure of perceptual impairment. Visuoconstructive, memory or verbal impairment were not related to disoriented behavior. Furthermore, when the influence of perceptual impairment was eliminated by calculating partial correlations, the other correlations between memory, visuoconstructive or verbal impairment and disoriented showed a substantial decrease. Our results suggest a strong association between perceptual impairment in neuropsychological measures and disoriented behavior in familiar surroundings in mild Alzheimer''s disease.