FAD stage down to the dUMPs

摘要

An unexpected discovery could lead to new antibiotics claim researchers in the US.Amnon Kohen,at the University of Iowa,and colleagues were investigating the mechanism of the enzyme FDTS(flavin dependent thymidylate synthase).FDTS catalyses the conversion of dUMP,a derivative of the nucleoside uridine,to its thymidine analogue,dTMP,used in DNA formation.Kohen found that the substrate dUMP activates an initial stage in the enzyme's catalytic cycle:the reduction of the cofactor FAD(flavin adenine dinucleotide).