Ventilation-perfusion imaging with Xe-133 and Tc-99m MAA was performed to exclude pulmonary embolism in an increasingly dyspneic patient with known breast cancer. A CT scan 1 week earlier showed several small subpleural masses believed to represent metastatic disease. The perfusion images revealed multiple, bilateral, wedge-shaped defects. A pulmonary angiogram was normal. However, an open lung biopsy revealed extensive hematogenous tumor deposits.
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