An H‐Deficient Blood with NormalHTransferase Levels

摘要

Abstract.An H‐deficient blood is described which, unlike other H‐deficient, Bombay and para‐Bombay bloods, has normalHtransferase levels. In previous examples of Bombay and para‐Bombay phenotypes the absence ofHtransferase has explained the lack of H substrate and therefore the weak A and B antigens which are characteristic of these phenotypes. This explanation obviously does not hold in the case described here and it is proposed that the biochemical block must be further back, either in the enzymes synthesising the oligosaccharide chains or in those making the GDP‐fucose substrate for theHand theLegene‐specified fucosyltransferases. Inhibition of the synthesis of Lebsubstance, as well as H substance, although the saliva of the propositus contains theLegene‐specified transferase, supports thi