BACKGROUND: The present study investigates the regulative retinal vascular answer to flicker as measured by Dynamic Vessel Analysis (DVA) in relation to age. MATERIAL/METHODS: 52 clinically healthy volunteers (age 20-78 years) free of cardiovascular risk factors according to an extensive medical history, lab values and blood pressure (BP) were examined by retinal DVA. The regulative arterial and venous responses to flicker were recorded with a Retinal Vessel Analyzer (Imedos, Jena/Germany). RESULTS: The retinal arterial regulative amplitude, consisting of a dilation and constriction component, diminished by 45 with age, mainly due to the constricting component diminishing by 75. The venous response to flicker was unaltered. CONCLUSIONS: The vascular regulative amplitude as well as its constriction part are observable in retinal arteries. They undergo major reduction in healthy individuals during adult lifetime. The results can be explained by the change of biomechanical properties of the vessel wall as well as physiological changes of the vascular endothelial function with age. Hereby the DVA technique shows good potential for investigating cardiovascular aspects in preventive medicine. Whenever doing functional DVA testing these results should be taken in account. The data obtained are first normative age related DVA data.
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机译：背景：本研究调查了通过动态血管分析 （DVA） 测量的与年龄相关的闪烁的调节性视网膜血管反应。材料/方法： 52 名临床健康志愿者（年龄 20-78 岁）根据广泛的病史、实验室值和血压 （BP） 通过视网膜 DVA 检查，没有心血管危险因素。使用视网膜血管分析仪（Imedos，耶拿/德国）记录对闪烁的调节性动脉和静脉反应。结果：视网膜动脉调节振幅，由扩张和收缩成分组成，随着年龄的增长而减少 45%，主要是由于收缩成分减少了 75%。静脉对闪烁的反应没有改变。结论：在视网膜动脉中可观察到血管调节幅度及其收缩部分。它们在成年后会经历健康个体的大幅减少。结果可以通过血管壁生物力学性质的变化以及血管内皮功能随年龄的增长而发生的生理变化来解释。因此，DVA技术在预防医学中研究心血管方面显示出良好的潜力。每当进行功能性DVA测试时，都应考虑这些结果。获得的数据是第一个与年龄相关的规范 DVA 数据。
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