The authors report a case of histologically proved Warthin's tumor of the parotid gland that caused a false-positive result of an I-131 body scan. Because patients with distant metastases that concentrate I-131 should receive I-131 therapy, it is extremely important to properly distinguish false-positive sites of I-131 localization to avoid unnecessary therapeutic intervention. Warthin's tumor should be included in the differential diagnosis when nonphysiologic radioiodine accumulation is encountered in the region of the salivary glands.
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