Oral Minocycline Improved Keratosis Follicularis Squamosa (Dohi) and Related Disorder: Bacterial Factors are Possibly Involved in Abberant Keratinization

摘要

AbstractThree cases of keratosis follicularis squamosa (Dohi) and one case of papillomatose confluente et reticulee were successfully treated with oral minocycline (50‐100 mg/day). The clinical effect first appeared at 2 weeks after the initiation of therapy and no recurrence was observed for more than 3 months without minocycline. Gram positive cocci were demonstrated inside the hair follicle and horny layers in all 4 case. Minocycline might modulate abberant keratinization through its bactericidal effects in these keratinizing disorder