Abstract.192 sera containing cold agglutinins of apparent anti‐I specificity were reinvestigated for concomitant cold agglutinins (CA) against sialic acid‐dependent antigens. 35 cases of additional anti‐Fl and 3 cases of additional anti‐Gd were detected. 53 of cases with coexisting anti‐I and anti‐Fl/Gd CA had a clinical diagnosis of pneumonia, in 39 IgM antibodies againstMycoplasma pneumoniaecould be demonstrated. Since Fl and Gd antigens are identical with the structures identified as receptors forM.pneumoniae, the findings support the hypothesis that postinfectious CA are directed against the receptor of the infec
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