Protease Modification Enhances Anti‐D Binding to Nucleated Red Blood Cell Precursors1

摘要

AbstractProtease modification of nucleated red blood cell precursors resulted in significant enhancement of anti‐D binding, indicating the presence of cryptic Rh determinants within the plasma membrane of the developing erythroid cell. Protease‐modified nucleated precursor cells bound less anti‐D than protease‐modified mature red blood cells, however, suggesting that the total content of D antigen in the developing erythropoietic plasma membrane is reduced. These findings support the hypothesis that the D antigen, an integral membrane protein, is progressively synthesized during erythro