Differential sensitivity of memory cell subpopulations to anti‐immunoglobulin and complement

摘要

AbstractEvidence is presented for the unique sensitivity of memory cells bearing surface immunoglobulin G1(IgG1) to functional elimination with anti‐immunoglobulin (anti‐Ig) sera and complement (C). Treatment of cells for adoptive transfer with C and anti‐γ1, anti‐K, or anti‐Ig significantly reduces the number of plaque‐forming cells (PFC) of only the IgG1isotype found in adoptive recipients. An increase in PFC of other isotypes accompanies the decrease in IgG1PFC; there is no net change in the total PFC response. The depletion of IgG1PFC requires treatment of transferred cells with both specific antisera and C; antisera directed against other isotypes show no significant effects. The maintenance of the magnitude of PFC response, compensation,