Diabetic ulcer is a major complication of diabetes with a high burden on society resources. Despite concerted efforts in improving diabetes care, delayed wound healing in diabetes remains a common, dreaded complication 1. The pathogenic mechanisms behind impaired wound healing in diabetes are poorly understood, and therefore, no specific targeted therapy is available.Aging also impairs the wound healing capacity by mechanisms that are still unraveled but can be partially explained by a decline in the production of sex steroid hormones since the defect is improved by topically or systemically delivered estrogen replacement therapy 2, 3. A predominance of diabetic foot ulcers in males suggest that estrogens might be beneficial for wound healing in diabetes which is sustained experimentally in diabetic animals 4.
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