A review of the published literature over the past 30 years provides evidence that antidepressants are rarely associated with substance abuse and substance dependence as described by DSM-IV criteria.Reported data do not support the designation of antidepressants as substances of abuse or their general regulation by control acts or schedules. However, the data do support the recommendation that they be used with caution among people who have concurrent substance use disorders or personality disorders (e.g. antisocial personality disorder), who have a high proclivity toward substance abuse or dependence.As with other drugs, all people who use antidepressants require appropriate information regarding the associated risks and benefits of their drug therapy, and instruction regarding correct therapeutic use. They should also be monitored to ensure optimal therapeutic benefit with minimal adverse drug effects.
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