This study indicates that chlorhexidine gluconate adsorbs to hydroxyapatite, tooth surfaces and salivary mucins and that the adsorbed chlorhexidine is released when the concentration in the environment is low. The possible formation of reservoirs of chlorhexidine on the tooth surfacein vivofrom which chlorhexidine is slowly released could, therefore, prevent bacterial colonization and the development of dental plaque.
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