Alpha-2-Macroglobulin-Kallikrein Complex: A Temperature-Sensitive Mediator in Contact-System-Induced Inflammation with a Potential Role in Late and Delayed Hypersensitivity Responses

摘要

Maximal complexing of α2-macroglobulin (α2M) and kallikrein (KK) occurs at a temperature of 22–24 rather than at 37 °C. The protease expressivity of the complex is also maximal at 22–24 °C. α2M-KK complex, sustained permeability changes in guinea pig skin. These findings suggest that the complex, rather than free KK, could play a role in the kinin release reported in some late-phase reactions, some instances of delayed-type hypersensitivity and some cold-induced r