Development of selective igm deficiency in systemic lupus erythematosus patients with disease of long duration

摘要

AbstractStatistical analysis of serum immunoglobulin levels in 54 systemic lupus erythematosus (SLE) patients showed a decrease in serum IgM (normal 77 ± 26 mg/dl;P<0.001) that was closely related to disease duration. The longer the duration of SLE, the more striking the decrease in serum levels of IgM (r = −0.74, P<0.01). Selective IgM deficiency (<47 mg/dl) occurred in SLE patients whose disease was clinically inactive or less acti