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>Simultaneous Determination of Bromvaletone and Propantheline Bromide in Tablets by High-Performance Liquid Chromatography
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Simultaneous Determination of Bromvaletone and Propantheline Bromide in Tablets by High-Performance Liquid Chromatography
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机译:Simultaneous Determination of Bromvaletone and Propantheline Bromide in Tablets by High-Performance Liquid Chromatography
A simple, rapid and accurate high-performance liquid chromatographic (HPLC) procedure was proposed for the simultaneous determination of bromvaletone and propantheline bromide in tablets using carbamazepine as an internal standard. The method employs a reversed-phase column with a mobile phase of acetonitrile/0.05M phosphate buffer pH 2.7 (40 : 60) mixture. The effluent was monitored by a UV detector at 220nm. A simple procedure to extract the active components with acetonitrile was used. The results showed that good resolution and reproducibility can be achieved. A linear relationship was found between peak height ratio and a concentration range of 5 to 30 #x3BC; g/mL. By varying the active/excipient ratio, we obtained a mean recovery of 99.4 for bromvaletone and 99.2 for propantheline bromide. The chromatographic separation in this study can be completed within ten minutes.
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